鉤藤堿

分析標準品,HPLC≥98%

Rhyncholphylline

CAS號：76-66-4

分子式：C22H28N2O4

分子量：384.47

MDL：MFCD00221748

產(chan) 品介紹

熔點：216℃

沸點：560.8 ℃ at 760 mmHg

比旋光度：D13 -14.7° (c = 2.5 in chloroform)

外觀：白色結晶

溶解性：溶於(yu) 氯仿、丙tong、乙醇、苯，微溶於(yu) 乙mi和醋酸乙酯，幾乎不溶於(yu) 石油醚。

儲(chu) 存條件：2-8℃

注意：部分產(chan) 品我司僅(jin) 能提供部分信息，我司不保證所提供信息的權威性，僅(jin) 供客戶參考交流研究之用。

參考文獻(28篇)

28. [IF=6] Tao Hu et al."Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosesynthesis of Bioactive Alkaloids."PLANT CELL AND ENVIRONMENT.2024 Nov;:

27. [IF=6.9] Lei Panpan et al."Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions."ARCHIVES OF PHARMACAL RESEARCH.2024 Dec;:1-13

26. [IF=6.8] Lin Lin et al."Rhynchophylline as an agonist of sirtuin 3 ameliorates endothelial dysfunction via antagonizing mitochondrial damage of endothelial progenitor cells."BRITISH JOURNAL OF PHARMACOLOGY.2025 Mar;:

25. [IF=1.3] Yongzhou Yu et al."Integrated UPLC-MS and multivariate data processing approach to explore the chemical components of Uncaria rhynchophylla and its absorbed components in rats following oral adminstration."JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNO

24. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS

23. [IF=5.811] Liu  Jiao et al."Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy."Frontiers in Pharmacology. 2022 Apr;0:1375

22. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607

21. [IF=2.649] Long Hongyan et al."Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF‐κB pathways."Environ Toxicol. 2019 Oct;34(10):1114-1120

20. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

19. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384

18. [IF=3.996] Jiang  Pan et al."Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation."Neurochem Res. 2021 Sep;46(9):2439-2450

17. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo

16. [IF=1.908] Xin  Wang et al."Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry."Xenobiotica. 2017;47(6):479-487

15. [IF=3.935] Shuanglu Xie et al."Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra."J Pharmaceut Biomed. 2013 Jul;81-82:56

14.  鄧向濤,張文周,張智強.鉤藤堿納米混懸劑緩釋片製備、優(you) 化與(yu) 體(ti) 外釋放評價(jia) [J].中草藥,2020,51(20):5128-5136.

13.  範素芳, 馬俊美, 劉茁,等. 高效液相色譜-串聯質譜測定食品中15種有毒生物堿[J]. 食品科學, 2018, 39(22):290-295.

12.  郭曉敏, 黃寶媛, 曾常青. 鉤藤生物堿提取物及其單體(ti) 逆轉HepG2/ADM細胞耐藥活性的篩選[J]. 廣東(dong) 藥學院學報, 2018, 034(004):447-451.

11.  樊暉, 田原. 正交試驗優(you) 選天麻安神顆粒乙醇提取工藝[J]. 中國實驗方劑學雜誌, 2015, 21(7):21-23.

10.  劉明, 王慧森, 李更生. 春花降壓片的質量標準研究[J]. 西北藥學雜誌, 2020, v.35(03):9-12.

9.  張媛媛  曾慧婷  陳超 等. 以離子液體(ti) 為(wei) 流動相添加劑的HPLC法分離並測定鉤藤中鉤藤堿和異鉤藤堿的含量[J]. 中國藥房  2019  v.30;No.663(21):77-82.

8.  龍國友  王美  孫剛. HPLC法測定安樂(le) 片中鉤藤堿和異鉤藤堿的含量[J]. 中國藥品標準  2017(4).

7.  李素珍, 唐振祥, 吳衛. 鉤藤堿脂質體(ti) 的製備及釋放度研究[J]. 中華中醫藥雜誌, 2013, 028(012):3730-3732.

6.  趙興(xing) 業(ye) , 王穎慧, 崔曉鴿,等. 鉤藤堿雙層滲透泵控釋片的製備及處方優(you) 化[J]. 中成藥, 2020, v.42(05):17-21.

5.  徐有偉(wei) , 黃真, 周洪雷,等. 藤菔降壓片質量控製研究[J]. 中藥新藥與(yu) 臨(lin) 床藥理, 2015, 026(005):690-694.

4.  黃真, 周洪雷, 李運倫(lun) ,等. 藤菔降壓片指紋圖譜評價(jia) 體(ti) 係研究[J]. 遼寧中醫雜誌, 2014, 041(006):1251-1253.

3.  閆瑞, 李淩軍(jun) , 李順. 天鉤降壓膠囊中鉤藤堿大鼠體(ti) 內(nei) 藥動學研究[J]. 山東(dong) 中醫藥大學學報, 2014, 000(003):257-259.

2.  李季, 李淩軍(jun) , 婁華偉(wei) . 天鉤降壓膠囊中鉤藤堿、異鉤藤堿大鼠在體(ti) 腸吸收動力學研究[J]. 中國實驗方劑學雜誌, 2013, 19(6):167-170.

1.  婁華偉(wei) , 李淩軍(jun) , 李季. 天鉤降壓膠囊中鉤藤堿、異鉤藤堿在大鼠離體(ti) 小腸的吸收動力學研究[J]. 中國實驗方劑學雜誌, 2013, 19(7):150-153.